Coexistence of hepatocellular carcinoma (HCC) and c-Kit negative gastrointestinal stromal tumor (GIST): a case report.

A past history of sporadic solid cancers is disclosed in 10% of gastrointestinal stromal tumor (GIST) patients. Simultaneous occurrence with other malignancies is encountered in 14 to 16%, but the synchronous occurrence of GIST and hepatocellular carcinoma (HCC) has been reported only once in the English literature. An 81-year-old male patient is presented with a preoperatively known HCC, in whom a synchronous small nodular omental GIST adjacent to the lesser curvature of the stomach was incidentally discovered. When a GIST is encountered, a thorough intraoperative investigation of the abdominal cavity currently remains the only reliable method for detection of a possible coexisting malignancy.

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• Southern Medical Association
• Ovid Technologies, Inc.

Medical

• Gastrointestinal Stromal Tumors – Genetic Alliance
• Hepatocellular carcinoma, adult – Genetic Alliance
• Liver Cancer – MedlinePlus Health Information

Miscellaneous

• NCI CPTAC Assay Portal